1-((7,7-DIMETHYL-2(S)-(2(S)-AMINO-4-(METHYLSULFONYL)BUTYRAMIDO)BICYCLO[2,2,1]HEPTAN-1(S)-YL)METHYLSULFONYL)-4-(2-METHYLPHENYL)PIPERAZINE HYDROCHLORIDE
1-((7,7-DIMETHYL-2(S)-(2(S)-AMINO-4-(METHYLSULFONYL)BUTYRAMIDO)BICYCLO[2,2,1]HEPTAN-1(S)-YL)METHYLSULFONYL)-4-(2-METHYLPHENYL)PIPERAZINE HYDROCHLORIDE
CAS: 160312-62-9
Molecular Formula: C26H42N4O5S2
1-((7,7-DIMETHYL-2(S)-(2(S)-AMINO-4-(METHYLSULFONYL)BUTYRAMIDO)BICYCLO[2,2,1]HEPTAN-1(S)-YL)METHYLSULFONYL)-4-(2-METHYLPHENYL)PIPERAZINE HYDROCHLORIDE - Names and Identifiers
1-((7,7-DIMETHYL-2(S)-(2(S)-AMINO-4-(METHYLSULFONYL)BUTYRAMIDO)BICYCLO[2,2,1]HEPTAN-1(S)-YL)METHYLSULFONYL)-4-(2-METHYLPHENYL)PIPERAZINE HYDROCHLORIDE - Physico-chemical Properties
| Molecular Formula | C26H42N4O5S2 |
| Molar Mass | 554.77 |
| Solubility | H2O: 20 mg/mL, soluble |
| Appearance | powder |
| Color | white |
| Storage Condition | −20°C |
| In vitro study | L-368,899 hydrochloride is a potent, orally bioavailable, non-peptide oxytocin receptor antagonist, with IC 50 s of 8.9 nM and 26 nM for rat uterus and human uterus oxytocin receptor, respectively. L-368,899 is less active on VP receptor in human liver and kidney, rat liver and kidney (IC 50 , 510 nM, 960 nM, 890 nM, 2400 nM, respectively). |
| In vivo study | L-368,899 exhibits similar pharmacokinetics in rats and dogs. After a single iv. injection, L-368,899 had a t 1/2 of 2 hr in both species. Additionally, L-368,899 has a plasma clearance between 23 and 36 ml/min/kg in rats or dogs. L-368,899 exhibits V dss values of 2.0 and 2.6 liters/kg and 3.4 to 4.9 liters/kg for dogs, respectively. L-368,899 is orally available. In the rat, at the 5 mg/kg dose, the oral bioavailabilities are 14% and 18% for female and male rats, respectively. Additionally, the oral bioavailabilities are 17% and 41% for female and male rats, respectively at the dosage of 25 mg/kg. |
1-((7,7-DIMETHYL-2(S)-(2(S)-AMINO-4-(METHYLSULFONYL)BUTYRAMIDO)BICYCLO[2,2,1]HEPTAN-1(S)-YL)METHYLSULFONYL)-4-(2-METHYLPHENYL)PIPERAZINE HYDROCHLORIDE - Risk and Safety
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
1-((7,7-DIMETHYL-2(S)-(2(S)-AMINO-4-(METHYLSULFONYL)BUTYRAMIDO)BICYCLO[2,2,1]HEPTAN-1(S)-YL)METHYLSULFONYL)-4-(2-METHYLPHENYL)PIPERAZINE HYDROCHLORIDE - References
| biological activity | l-368,899 hydrochloride is a potent, selective, orally available, the non-peptide oxytocin receptor oxytocin receptor antagonist, with IC50 values of 8.9 nM and 26 nM for rat and human uterine oxytocin receptor, respectively, is an anti-preterm labor agent. |
| Target | IC50: 8.9 nM, 26 nM |
Last Update：2024-04-10 22:29:15
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View History
1-((7,7-DIMETHYL-2(S)-(2(S)-AMINO-4-(METHYLSULFONYL)BUTYRAMIDO)BICYCLO[2,2,1]HEPTAN-1(S)-YL)METHYLSULFONYL)-4-(2-METHYLPHENYL)PIPERAZINE HYDROCHLORIDE
Einecs 281-749-2
Oxirane, 2-(3-bromophenyl)-, (2S)-
3-硝柳酸
OTAVA-BB BB7020410158
2-CYCLOPROPYL-6-PHENYL-4-(TRIFLUOROMETHYL)NICOTINONITRILE
2-(3-氟苯氧基)-1-乙胺
1(S)-[1(R)-(DIMETHYLAMINO)ETHYL]-2-(DIPHENYL-PHOSPHANY)FERROCENE
Ethanol, 2-[(1-naphthalenylmethyl)thio]-
1-Bromo-3-chloropropane, [Trimethylene bromochloride]
Einecs 281-749-2
Oxirane, 2-(3-bromophenyl)-, (2S)-
3-硝柳酸
OTAVA-BB BB7020410158
2-CYCLOPROPYL-6-PHENYL-4-(TRIFLUOROMETHYL)NICOTINONITRILE
2-(3-氟苯氧基)-1-乙胺
1(S)-[1(R)-(DIMETHYLAMINO)ETHYL]-2-(DIPHENYL-PHOSPHANY)FERROCENE
Ethanol, 2-[(1-naphthalenylmethyl)thio]-
1-Bromo-3-chloropropane, [Trimethylene bromochloride]